Key Publications on the Science Behind Axerion’s Programs:

 

Prion Protein Inhibitor Program

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM. Nature. 2009 Feb 26;457(7233):1128-32.


Memory impairment in transgenic Alzheimer mice requires cellular prion protein.

Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Laurén J, Gimbel ZA, Strittmatter SM. J Neurosci. 2010 May 5;30(18):6367-74.
 

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse.

Chung E, Ji Y, Sun Y, Kascsak RJ, Kascsak RB, Mehta PD, Strittmatter SM, Wisniewski T. BMC Neurosci. 2010 Oct 14;11:130.

 

Alzheimer's Disease Brain-Derived Amyloid-{beta}-Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein.

Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, Walsh DM, Rowan MJ. J Neurosci. 2011 May 18;31(20):7259-63.

(Abstract only)
 

Nogo Decoy Receptor Program

Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.

Fournier AE, GrandPre T, Strittmatter SM. Nature. 2001 Jan 18;409(6818):341-6.

(Abstract only)
 

Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin.

Fournier AE, Gould GC, Liu BP, Strittmatter SM. J Neurosci. 2002 Oct 15;22(20):8876-83.

 

Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury.

Li S, Liu BP, Budel S, Li M, Ji B, Walus L, Li W, Jirik A, Rabacchi S, Choi E, Worley D, Sah DW, Pepinsky B, Lee D, Relton J, Strittmatter SM. J Neurosci. 2004 Nov 17;24(46):10511-20.
 

Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury.

Ji B, Li M, Budel S, Pepinsky RB, Walus L, Engber TM, Strittmatter SM, Relton JK. Eur J Neurosci. 2005 Aug;22(3):587-94.

Delayed Nogo receptor therapy improves recovery from spinal cord contusion.

Wang X, Baughman KW, Basso DM, Strittmatter SM. Ann Neurol. 2006 Nov;60(5):540-9.


MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma.

Cafferty WB, Duffy P, Huebner E, Strittmatter SM. J Neurosci. 2010 May 19;30(20):6825-37.

Recovery from Chronic Spinal Cord Contusion after Nogo Receptor Intervention

Xingxing Wang, Philip Duffy, Aaron W. McGee, Omar Hasan, Grahame Gould, Nathan Tu, Noam Y. Harel, Yiyun Huang, Richard E. Carson, David Weinzimmer, Jim Ropchan, Larry I. Benowitz, William B. J. Cafferty, and Stephen M. Strittmatter,  Ann. Neurol. 2011;70:805–821